RealBrain® Technology

Scalable 3D neural models that replicate essential features of the human brain.

The Technology That Unlocks Human Neuroscience

RealBrain® Platform

ArtiBrain™ - Healthy Human 3D micro-tissue (hyperlink)

Tessara’s RealBrain® platform uses a proprietary synthetic hydrogel that forms a brain-like extracellular matrix (ECM), providing neural stem cells with the structure they need to thrive. Engineered for optimal stiffness and gelation, it supports rapid network formation and allows cells to build their own ECM. With consistent, scalable manufacturing and low batch variation, RealBrain® ensures reliability at every stage, with specialised models—ArtiBrain™ for healthy baseline conditions and ADBrain™ for Alzheimer’s disease.

ADBrain™ - Alzheimer’s disease 3D micro-tissue (hyperlink)

Matrix-Guided Self-Assembly of Neural Micro-Tissues

Standardised. Scalable. Predictive.

RealBrain® micro-tissues, derived from human iPSCs, self-organise into stable 3D networks of neurons and glial cells within a self-secreted matrix, supporting electrical activity and synaptic function. Each well contains a single, uniform micro-tissue, enabling consistent results and scalable high-throughput drug discovery in standard microplane formats.

  • Chemically defined RealBrain® Matrix mimics CNS biological cues.

  • Promotes stem cell differentiation and natural ECM secretion.

  • Fully remodelled by cells during maturation.

RealBrain® Matrix

  • Matrix drives secretion of natural ECM, replacing synthetic polymers.

  • Natural ECM stores signalling molecules.

  • These signals regulate stem cell growth and differentiation.

Developing Networks

  • Forming extensive neuronal networks, diverse neuronal cell types, mimicking in-vivo tissue.

  • Cortical-like patterning and sulci.

  • Matrix replaced by cell-secreted ECM.

Mature Micro-Tissues

Drug Discovery Driven by Cellular Diversity

RealBrain® micro-tissues contain a heterogeneous population of neurons and glial cells that self-organise into functional networks. This cellular diversity mirrors the complexity of the human brain, enabling more accurate modelling of neural activity, support functions, and drug responses. Key neuronal and glial markers are consistently detected, confirming the identity and functionality of the cells within these networks.