ArtiBrain™ - Healthy Human 3D micro-tissue
Derived from human iPSCs, ArtiBrain™ provides a physiologically relevant model of the healthy brain. Within just three weeks, human neural stem cells give rise to multiple brain cells that self-organise to form dense synaptic networks embedded in their own secreted ECM — ready for drug discovery.
ArtiBrain™ brightfield image
GFAP-positive astrocytes
MAP2-positive neurons
RealBrain® Platform
Why ArtiBrain™
Reliable preclinical data depends on a robust reference point. ArtiBrain™ replicates key features of the healthy human brain and provides a reference for comparing disease models and quantifying drug effects. Whether you are assessing safety, mapping networks, or validating mechanisms, ArtiBrain™ delivers decision-ready data that reduces risk and accelerates progress.
A single population of human iPSC-derived Neural Stem Cell naturally mature giving rise to multiple neuronal subtypes and astrocytes — heterogeneous cell types forming functional synaptic networks.
Dense synaptic connectivity matured in ~21 days — rapid time-to-data compared with variable organoids.
Self-secreted extracellular matrix — high physiological relevance.
Single tissue per well — reproducibility across plates.
Standard 96- and 384-well formats — scalable for high-throughput screening.
Low variability across plates and batches — batch-QC assured with consistently low CV values.
Broad assay compatibility
Key Features
ArtiBrain™
What You Can Do With It
ArtiBrain™
ArtiBrain™ is compatible with virtually any assay — from high-content imaging to molecular and omics profiling — making it easy to integrate into your existing workflows. Tessara provides this model as a service, delivering end-to-end studies tailored to your discovery needs.
Our ArtiBrain™ Services offering includes:
Safety & Cytotoxicity Profiling – acute and chronic toxicity, oxidative stress, viability assays (e.g. Resazurin, LDH, CellTiter-Glo® 3D).
Neuroinflammation Assessment – GFAP quantification, cytokine and chemokine multiplex assays, secretome profiling.
Target Validation & Biomarker Discovery – Nf-L, PSD95, synapsin, S100B, transcriptomics and proteomics.
Neurodegeneration & Cell Death Pathway Analysis – ferroptosis detection and imaging of neuronal injury.
Neural Network Analysis – quantification of connectivity, axon length, branching, and plasticity using imaging.
Custom Assay Development – design of study protocols to fit unique mechanisms of action or compound classes.
ArtiBrain™ is the foundation for predictive neuroscience — reproducible, scalable, and human-relevant.
Put human biology at the centre of your discovery pipeline. With ArtiBrain™, you can generate clear, decision-ready data for safety, mechanism, and network analysis — all in a format designed for high-throughput workflows.